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ლოპერამიდი / Loperamide | მედიკამენტები | vidal.ge
Nuk

იხილეთ აფთიაქების ჩამონათვალი

ლოპერამიდი / Loperamide

შემადგენლობა

1 კაფსულა შეიცავს:
აქტიური ნივთიერება: ლოპერამიდის ჰიდროქლირიდი-2მგ
დამხმარე ნივთიერებები: ლაქტოზა, სიმინდის სახამებელი, მაგნიუმის სტეარატი.
კაფსულა: კორპუსი: ტიტანის დიოქსიდი (E 171), პატენტირებული ლურჯი V (E 131), ალისფერი 4R (E 124), ჟელატინი. სახურავი: ტიტანის დიოქსიდი (E 171), პატენტირებული ლურჯი V (E 131), ქინოლინის ყვითელი (E 104), რკინის ყვითელი ოქსიდი (E 172),ჟელატინი. 
აღწერილობა: მკვრივი ჟელატინის კაფსულები. კორპუსი ღია იისფერი, სახურავი მუქი მწვანე, კაფსულების შიგთავსი- თეტრი ფერის ფხვნილი.

ფარმაკოლოგიური თვისებები
აქვეითებს ნაწლავების გლუვი კუნთების ტონუსს და მოტორიკას, აფერხებს ნაწლავების შიგთავსის პასაჟს, ამცირებს სითხის და ელექტროლიტების გამოყოფას განავალთან ერთად. აძლიერებს ანალური სფინქტერის ტონუსს. მოქმედება იწყება სწრაფად და გრძელდება 4-6 საათის განმავლობაში.

ფარმაკოკინეტიკა
აბსორბცია – 40%. პლაზმის ცილებთან კავშირი შეადგენს 97%-ს. ნახევრად გამოყოფის პერიოდი შეადგენს დაახლოებით 9-14 საათს. არ გადის ჰემატოენცეფალურ ბარიერს. მეტაბოლიზმს განიცდის ღვიძლში კონიუგაციის გზით. გამოიყოფა უპირატესად ნაღველთან და შარდთან ერთად.

ჩვენებები
სხვადასხვა გენეზის მწვავე და ქრონიკული დიარეის სიმპტომატური მკურნალობა (ალერგიული, ემოციური, წამლისმიერი, სხივური; კვების რეჟიმის და საკვების შემცველობის ხარისხის დარღვევა; მეტაბოლიზმის და შეწოვის პროცესის დარღვევა; როგორც დამატებითი საშუალება ინფექციური წარმოშობის დიარეის სამკურნალოდ).
დეფეკაციის რეგულირება პაციენტებში ილეოსტომით.

მიღების წესები და დოზები
მოზრდილებში მწვავე და ქრონიკული დიარეის დროს ენიშნებათ დასაწყისში 2 კაფსულა (4მგ), ხოლო შემდგომ 1 კაფსულა (2მგ) თხიერი განავლის შემთხვევაში ყოველი დეფეკაციის შემდეგ. პრეპარატის მაქსიმალური სადღეღამისო დოზა შეადგენს 8 კაფსულას (16მგ).
ბავშვებს 6 წლის ასაკის ზემოთ ენიშნებათ 1 კაფსულა (2მგ) თხიერი განავლის შემთხვევაში ყოველი დეფეკაციის დროს. მაქსიმალური სადღეღამისო დოზა-3 კაფსულა (6მგ).
დეფექაციის ნორმალიზაციის შემდეგ ან მისი არარსებობის დროს 12 სთ-ზე მეტი ხნის განმავლობაში საჭიროა ლოპერამიდით მკურნალობის შეწყვეტა.

გვერდითი მოვლენები
შესაძლებელია თავის ტკივილი, გასტრალგია, პირის სიმშრალე, ალერგიული რეაქციები (კანზე გამონაყარი), ძილიანობა ან უძილობა, თავბრუსხვევა, ნაწლავური კოლიკა, გულისრევა, ღებინება. ძალზე იშვიათად- ნაწლავური გაუვალობა.

უკუჩვენება
მომატებული მგრძნობელობა პრეპარატის მიმართ, დივერტიკულოზი, ნაწლავთა გაუვალობა, წყლულოვანი კოლიტი გამწვავების სტადიაში, დიარეა მწვავე ფსევდომემბრანული კოლიტის ფონზე, მონოთერაპიის სახით- დიზენტერია და კუჭ-ნაწლავის ტრაქტის სხვა ინფექციები, ორსულობის I ტრიმესტრი და ლაქტაციის პერიოდი. 
ლოპერამიდი არ ინიშნება 6 წლამდე ასაკის ბავშვებში.
სიფრთხილით- ღვიძლის უკმარისობის დროს.

განსაკუთრებული მითითებები
სიფრთხილე:
თუ ლოპერამიდით მკურნალობის ფონზე 2 დღეში არ მიიღწევა ეფექტი, საჭიროა დიაგნოზის დაზუსტება და ინფექციური დიარეის გამორიცხვა.

ჭარბი დოზირება
სიმპტომები: ც.ნ.ს-ის დათრგუნვის ნიშნები (სტუპორი, მოძრაობის კოორდინაციის დარღვევა, ძილიანობა, მიოზი, ჩონჩხის კუნთების ტონუსის მომატება,სუნთქვის დათრგუნვა), ნაწლავების გაუვალობა.
მკურნალობა: ანტიდოტი- ნალოქსონი, ვინაიდან ლოპერამიდის მოქმედების ხანგრძლივობა მეტია ვიდრე ნალოქსონის, შესაძლებელია ნალოქსონის განმეორებითი შეყვანა. სიმპტომური მკურნალობა: კუჭის ამორეცხვა, გააქტივებული ნახშირის მიღება, ფილტვების ხელოვნური ვენტილაცია. საჭიროა სამედიცინო კონტროლი 48სთ-ის განმავლობაში.

შენახვის პირობები და ვადები
არა უმეტეს 25°C ტემპეტატურაზე. ინახება ბავშვებისთვის მიუწვდომელ ადგილას.
შენახვის ვადა:
5 წელი. არ გამოიყენოთ შეფუთვაზე მითითებული ვადის ამოწურვის შემდეგ!

აფთიაქში გაცემის წესი
გაიცემა ურეცეპტოთ. 

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